2 edition of Measuring octanol/water partition coefficients by the slow-stirring method found in the catalog.
Measuring octanol/water partition coefficients by the slow-stirring method
J. Jackson Ellington
1996 by U.S. Environmental Protection Agency, National Exposure Research Laboratory in Research Triangle Park, NC .
Written in English
|Other titles||Measuring octanol water partition coefficients by the "slow-stirring" method|
|Statement||J. Jackson Ellington and Terry L. Floyd|
|Series||Environmental research brief|
|Contributions||Floyd, Terry L, National Exposure Research Laboratory (U.S.)|
|The Physical Object|
|Pagination||3,  p. :|
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A new direct method for the determination of 1-octanol−water partition coefficients (Kow, expressed as log Kow) Measuring octanol/water partition coefficients by the slow-stirring method book presented.
In the experimental setup, a dialysis tubing separates water from the octanol phase containing the analyte. This prevents the system from the frequently encountered problem of emulsions. Several tubings with molecular weight cutoffs between Cited by: The "slow-stirring" method minimizes the formation of emulsions and enables the laboratory measure- ment of chemicals with a log K^ greater than 8.
The tech- niques and equipment are described. Introduction The octanol/water partition coefficient (K^) Measuring octanol/water partition coefficients by the slow-stirring method book the physico- chemical parameter most commonly measured in the labora- tory and used to.
Octanol:Water partition coefficients (P): Measurement, estimation, and interpretation, particularly for chemicals with P > 10e5.
Ecotoxicology and Environmental Safety de Bruijn JHM, Busser F, Seinen W, Hermens J. Determination of octanol/water partition coefficients with the ’slow-stirring’ method. Environ. Toxicol File Size: KB. Measuring octanol/water partition coefficients by the "slow-stirring" method Author: J Jackson Ellington ; Terry L Floyd ; National Exposure Research Laboratory (U.S.).
The method also struggles with insoluble compounds and self-evidently is not suitable for neutral compounds. OECD – Partition coefficient (n-octanol/water): Slow-stirring. The ‘shake-flask’ method (OECD ) is prone to artefacts due Measuring octanol/water partition coefficients by the slow-stirring method book transfer of octanol micro droplets into the aqueous phase.
Octanol–water partition coefficients (K OW) K OW values for 13 polycyclic aromatic hydrocarbons were determined with the gold standard “slow‐stirring” method (log K OW –).
These values were then used as reference data for the development of an alternative method for measuring K OW. This approach combined slow stirring and Cited by: 6. This Test Guideline describes the slow-stirring method, which permits the determination of the 1-octanol/water partition coefficient (POW) values up to a log POW of The partition coefficient between water and 1-octanol (POW) is defined as the ratio of the equilibrium concentrations of the pure test substance in 1-octanol saturated with.
Methods for measurement and estimation of octanol:water partition coefficients are discussed with particular reference to high values (log P > 5). A novel experimental method for P measurement is described and preliminary results presented.
The use of high performance liquid chromatography capacity factors for estimating P values has been investigated; better Cited by: This Test Guideline describes the slow-stirring method, which permits the determination of the 1-octanol/water partition coefficient (POW) values up to a log POW of The partition coefficient between water and 1-octanol (POW) is defined as the.
This method can not be used with surface-active materials. The partition coefficient is defined as the ratio of the equilibrium concentrations of a dissolved substance in a two-phase system consisting of two largely immiscible solvents.
The test should be done at a temperature in the range 20 to 25°C, kept constant at ± 1°. Slow-stirring method for determining the n-octanol/water partition coefficient (Pow) for highly hydrophobic chemicals: performance evaluation in a ring test.
Tolls J(1), Bodo K, De Felip E, Dujardin R, Kim YH, Moeller-Jensen L, Mullee D, Nakajima A, Paschke A, Pawliczek JB, Schneider J, Tadeo JL, Tognucci AC, Webb J, Zwijzen by: A new direct method for the determination of 1-octanol−water partition coefficients (Kow, expressed as log Measuring octanol/water partition coefficients by the slow-stirring method book is presented.
In the experimental setup, a. Partition Coefficient (n-octanol/water), High Performance Liquid Chromatography (HPLC) Method Introduction 1. The partition coefficient (P) is defined as the ratio of the equilibrium concentrations of a dissolved substance in a two-phase system consisting of two largely immiscible solvents.
In the case of n-octanol and water,File Size: 82KB. Nonionic Surfactants: Octanol-Water Partition Coefficients with the Slow Stirring/Surface Tension Method Article in Tenside Surfactants Detergents 49(2) March with Reads.
n-octanol/water partition coefficient, P ow. J., Determination of octanol/water partition coefficient for hydrophobic organic chemicals with the “slow-stirring” method.
Environmental Toxicology Chemical, 8, – R. A., Eisenreich, S. J., Chromatographic determination of octanol-water partition coefficients (Kow’s Cited by: 1. n-Octanol/water partition coefficients (P) for DDTs and dicofol were determined by reversed-phase high performance liquid chromatography (RP-HPLC) on a C 18 column using methanol–water mixture as mobile phase.
A dual-point retention time correction (DP-RTC) was proposed to rectify chromatographic retention time (t R) shift resulted from stationary phase Cited by: Surfactants are widely used across the globe both in industrial and consumer products.
The n-octanol/water partition ratio or coefficient (log Kow) and n-octanol/water distribution coefficient (log D) are key parameters in environmental risk assessment of chemicals as they are often used to estimate the environmental fate and bioavailability and thus Cited by: 7.
The octanol-water partition coefficients were determined using the slow-stirring method in a mL Erlenmeyer flask. A magnetic stir bar was placed in the mL Erlenmeyer flask. mL of deionized water was measured using a Fisherbrand Finnpipette II and pipetted into the.
The n-octanol/water partition coefficient (KOW) is a physical/chemical property that is extensively used for regulatory and environmental risk and exposure assessments. The KOW value can estimate various chemical properties such as water solubility, bioavailability, and toxicity using quantitative structure-activity relationships which demands an accurate Cited by: 1.
We describe a simple miniature shake-flask method to measure the octanol–water partition coefficient of an organic compound. Partition between water and octanol is performed in an NMR tube; the aqueous phase is analyzed by 1H NMR spectroscopy using a benchtop low-field NMR instrument.
Neither pre-equilibration of solvents nor isolation of the two phases is by: octanol/water partition coefﬁcients for hydrophobic organic chemicals with the “slow-stirring” method. Environ Toxicol Chem 8: – Organisation for Economic Cooperation and Development.
Partition coefﬁcient (1-octanol/water): Slow-stirring method. Test guideline Paris, France. Cited by: 3 32 1. INTRODUCTION 33 The octanol-water partition coefficient (Kow) and water solubility play an important role in 34 determining the partitioning behavior of chemicals in the environment .
In particular, Kow serves 35 not only as a general indicator of a compound’s tendency to partition into an organic phase, but.
en This Test Method is equivalent to OECD Test Guideline (TG) (). 1-octanol / water partition coefficient (POW) values up to a log POW of 8,2 have been accurately determined by the slow-stirring method (1). Brooke and co-workers () have described a "slow-stir" method for measuring octanol/water partition coefficients for hydrophobic chemicals.
This method is similar to the shake-flask method, but differs in that the octanol and water phases are equilibrated under conditions of slow stirring rather than vigorous shaking.
The road to nowhere: equilibrium partition coefficients for nanoparticles. Antonia Praetorius * a, Nathalie Tufenkji b, Kai-Uwe Goss c, Martin Scheringer a, Frank von der Kammer d and Menachem Elimelech e a Institute for Chemical and Bioengineering, Swiss Federal Institute of Technology – ETH Zurich, Vladimir-Prelog-Weg 1, Zurich, by: Determination of Octanol/Water Partition Coefficients for Hydrophobic Organic Chemicals with the ``Slow-stirring'' Method.
Environ. Toxicol. Chem. DeVoe, H., M.M. Miller and S.P. Wasik. Generator Columns and High Pressure Liquid Chromatography for Determining Aqueous Solubites and Octanol-Water Partition Coefficients of Hydrophobic.
The evaluation of the lipophilic characteristics of biologically active agents is indispensable for the rational design of ADMET-tailored structure–activity models. N-Alkoxyhydroxynaphthalenecarboxanilides, N-alkoxyhydroxynaphthalenecarboxanilides, and N-alkoxyhydroxynaphthalenecarboxanilides were recently reported as a series of compounds with Cited by: 4.
Background. Surfactants are widely used across the globe both in industrial and consumer products. The n-octanol/water partition ratio or coefficient (log K ow) and n-octanol/water distribution coefficient (log D) are key parameters in environmental risk assessment of chemicals as they are often used to estimate the environmental fate and Cited by: 7.
Explosive compounds have been released into the environment during manufacturing, handling, and usage procedures.
These compounds have been found to persist in the environment and potentially promote detrimental biological effects. The lack of research on bioaccumulation and bioconcentration and especially dietary transfer on aquatic life has resulted in challenges in Cited by: 9.
Temperature Dependence of the Organic Carbon/Water Partition Ratios (KOC) of Volatile MethylsiloxanesCited by: 8. Partition coefficient n-octanol/water (K.
ow, log value) at 25°C Experimental value (slow stirring method) taken from EA (a). VII, Dissociation constant (pKa) Not relevant. EA (a). MANUFACTURE AND USES.
Four companies produce or supply D5 in the EU (EA, a). The actual quantity producedFile Size: KB. The slow-stirring method was used to determine the partition constant (K D °). Three milliliter of water containing a known amount of IL ( mM) was added to a flask and then 1-octanol (3 mL) was carefully added.
The sample was stirred slowly for 24 h and then the water was separated from 1-octanol and analyzed in an optical absorption Cited by: 4. Page General Papers ARKIVOC (ix) Hydrocarbon normal boiling point data Octanol/water partition coefficient (logKOW) Industrial pollutants JP-8 mixture database Inhibition of complement Inhibition of microsomal p-hydroxylation of aniline Acute aquatic toxicity CRC identified.
The octanol-water partition coefficient for surfactants can not be determined using the shake-flask or slow stirring method because of the formation of emulsions. In addition, the surfactant molecules will exist in the water phase almost exclusively as ions, whereas they will have to pair with a counter-ion in order to be dissolved in octanol.
A novel method for measuring membrane-water partition coefficients of hydrophobic organic chemicals: comparison with 1-octanol-water partitioning, J. Pharm.
Sci., 77(3), A valuable enhancement to this edition is the inclusion of extensive measured temperature-dependent data for the first time. The data focus on water solubility, vapor pressure, and Henry’s law constant but include octanol/water and octanol/air partition coefficients where available.
First, from time to time EPA recalculates the (a) water quality criteria to reflect the latest data. These recalculations have been compiled in a series of guidance documents: the Green Book inthe Blue Book inthe Red Book inand the Gold Book in The second responsibility pertains to the requirements of Section (c).
The octanol-air partition coefficient, Koa and octanol-water partition coefficient, Kow. Introduction. The octanol-air and octanol-water partition coefficients, Koa (L/L) and Kow (L/L) are key equilibrium parameters for hydrophobic substances in fate models.
They are used as descriptors to estimate endpoints for such by: 1. n-Octanol/water partition coefficients (logKow) for persistent organic pollutants (POPs) including polycyclic aromatic hydrocarbons (PAHs), polychlorinated dibenzo-p-dioxins (PCDDs), polychlorinated dibenzofurans (PCDFs) and decabromodiphenylethane (DBDPE) have been determined by a modified method of reversed-phase high performance liquid Cited by: 1.
This banner text can have markup. web; books; video; audio; software; images; Toggle navigation. Pdf the octanoVwater system, a whole pdf of partition coefficients were measured, and thus a new hydrophobic scale was introduced (17).
The parameter a, which is the relative hydrophobicity of a substituent, was defined in a manner analogous to the definition of sigma (18). P, and P, represent the partition coefficients.
[Determination of equilibrium solubility and n-octanol/water partition coefficient of pulchinenosiden D by HPLC]. PubMed. Rao, Xiao-Yong; Yin, Shan; Zhang, Guo-Song; Luo, Xiao-Jia.Dernière Activité.
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